Tiflis, Gürcistan'da doğan Nino Machaidze: Royal Opera House – Covent Garden, Metropolitan Opera, Opera National de Paris, Münih'teki Bavarian State Opera, Berlin State Opera, Deutsche Oper Berlin, Milan'daki Teatro alla Scala, Madrid'deki Teatro Real, Vienna State Opera, Barselona'daki Gran Teatre del Liceu, Brüksel'deki Theatre Royale de la Monnaie, Valensiya'daki Palau de les Arts, Arena di Verona ve Los Angeles Opera gibi pek çok tiyatroda uluslararası düzeyde önemli sahne başarıları olan, günümüzün en parlak sanatçılarından biridir.
Nino Machaidze was born and raised in Tblisi, in the republic of Georgia. At the age of seven she began piano and vocal lessons at a school affiliated with the Tblisi State Conservatory, which she later also attended. At the age of 17, she sang Norina in Don Pasquale at Tbilisi's Paliashvili Theatre, followed by Zerlina (from Mozart's 'Don Giovanni') and Rosina (from Rossini's 'Barber of Seville') She was then accepted at the Academy for young artists at La Scala, Milan. In 2006 she won the Leyla Gencer Vocal Competition.
In the same year, she made her debut at La Scala singing Marie, the lead in Donizetti's 'La fille du régiment', which she also reprised at the Rome Opera.